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Frontiers | Case Report: Changes in Cytokine Kinetics During the Course of Disease in a Japanese Patient With Multisystem Inflammatory Syndrome in Children

Frontiers | Case Report: Changes in Cytokine Kinetics During the Course of Disease in a Japanese Patient With Multisystem Inflammatory Syndrome in Children
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Mammals can use their intestines to breathe

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Rodents and pigs share with certain aquatic organisms the ability to use their intestines for respiration, finds a study publishing May 14th in the journal
Med. The researchers demonstrated that the delivery of oxygen gas or oxygenated liquid through the rectum provided vital rescue to two mammalian models of respiratory failure.
Artificial respiratory support plays a vital role in the clinical management of respiratory failure due to severe illnesses such as pneumonia or acute respiratory distress syndrome, says senior study author Takanori Takebe (@TakebeLab) of the Tokyo Medical and Dental University and the Cincinnati Children s Hospital Medical Center. Although the side effects and safety need to be thoroughly evaluated in humans, our approach may offer a new paradigm to support critically ill patients with respiratory failure. ....

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Longitudinal antibody repertoire in "mild" versus "severe" COVID-19 patients reveals immune markers associated with disease severity and resolution

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A to
K) Viral load in upper respiratory tract of the 11 patients with COVID-19 at various time points as measured by RT–quantitative PCR (qPCR) (blue symbols). SARS-CoV-2–neutralizing antibody titers in serum/plasma for six severe (A to F; red symbols) and five mild (G to K; green symbols) COVID-19 patients at various time points as determined by PRNT50. (
L to
O) Cytokine levels (L, IL-6; M, IL-8; N, MCP-1; and O, MIP-1β) of fourfold diluted plasma/serum samples at various time points in the 11 patients with COVID-19 as analyzed via a Bio-Plex Pro Human Cytokine Panel 17-Plex assay. ( ....

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Crisis Response Must Take Gender into Account

Growing up with feminist parents active in social justice, Dyan Mazurana, a research professor at the Friedman School of Nutrition Science and Policy and The Fletcher School, has pondered the intersections of gender, race, age, ability, disability, and sexuality for most of her life. Since her early days as an undergraduate through to her time now as a Tufts professor, she has focused on understanding, preventing and responding to violence against women and children.
The coronavirus has pushed gender perspectives to the forefront even more. “The pandemic is the perfect lens through which to view factors of sex, gender, and race, among others, because those factors are literally determining who lives and who dies,” said Mazurana, who also directs the research program on women, children, and armed conflict at the Feinstein International Center. ....

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