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Epigenomic Map Identifies Candidate Mechanisms for 30,000 Gene Loci Linked to 540 Traits February 4, 2021 A team of researchers at Massachusetts Institute of Technology (MIT) has published what it claims is the most comprehensive map yet of human noncoding DNA. The EpiMap (Epigenome Integration across Multiple Annotation Projects) resource offers an in-depth annotation of epigenomic marks—modifications indicating which genes are turned on or off in different types of cells—across 833 tissues and cell types. This represents a significant increase over prior coverage, the team said. The res...

 E-Mail CAMBRIDGE, MA -- Twenty years ago this month, the first draft of the human genome was publicly released. One of the major surprises that came from that project was the revelation that only 1.5 percent of the human genome consists of protein-coding genes. Over the past two decades, it has become apparent that those noncoding stretches of DNA, originally thought to be "junk DNA," play critical roles in development and gene regulation. In a new study published today, a team of researchers from MIT has published the most comprehensive map yet of this noncoding DNA. This map provides in-d...