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The wreck was reported at around 5 p.m. EDT near Mile Marker 358 with the left shoulder blocked, as well as a lane of traffic.
Most East Tennessee schools are running low on their budgeted days off, and some like Knox County have run out after canceling classes again on Wednesday.
Leaders in Roane County warned salt and brine may not be enough to keep roads safe, urging people to stay home Thursday night.
The sheriff's office said the victim may have accidentally shot himself.
Authorities said Brian Wilson fatally shot a woman and wounded two other people in March.