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In a little under a year, scientists developed several vaccines against COVID-19. But as we line up for our shots, we are still living in the shadow of another pandemic. The search for a vaccine against HIV, the virus that causes AIDS, has been ongoing for nearly four decades. To this day, only one large-scale trial has demonstrated even marginal efficacy at preventing infection from the virus: the RV144 trial in Thailand—the largest HIV vaccine trial in history. After HIV was discovered in 1983, some scientists “hoped that a vaccine for AIDS could be forthcoming within two years,” writ...