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New tools enable rapid analysis of coronavirus sequences and tracking of variants


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IMAGE: In this example of UShER results, displayed using Nextstrain, sequences representing a hypothetical outbreak are yellow, previously sampled sequences are blue, and branches are labeled by nucleotide mutations.
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Credit: UC Santa Cruz Genomics Institute
The COVID-19 pandemic has spurred genomic surveillance of viruses on an unprecedented scale, as scientists around the world use genome sequencing to track the spread of new variants of the SARS-CoV-2 virus. The rapid accumulation of viral genome sequences presents new opportunities for tracing global and local transmission dynamics, but analyzing so much genomic data is challenging.
There are now more than a million genome sequences for SARS-CoV-2. No one had anticipated that number when we started sequencing this virus, said Russ Corbett-Detig, assistant professor of biomolecular engineering at UC Santa Cruz. ....

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