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Mrs Kirkham's Lancashire Cheese was established in 1978 by Ruth and John Kirkham before they handed it over to their son, Graham.
The outbreak of the diarrhoea-causing bacteria has affected children as young as seven, with MailOnline understanding a death has been reported in Scotland.
Mrs Kirkham's Lancashire Cheese is suspected by officials of being the epicentre of the outbreak, linked to artisan cheese sold in Waitrose and contained in Christmas hampers.
The victims are among 30 cases reported across the country, some involving children as young as seven - according to UK health and food watchdogs.
Graham Kirkham, who runs Mrs Kirkham's Lancashire Cheese dairy farm in Preston, is thought to be the epicentre of an E.coli outbreak that has left dozens of Brits ill over the Christmas period