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Using iodine as catalyst to advance the sustainability of pharmaceutical syntheses


Using iodine as catalyst to advance the sustainability of pharmaceutical syntheses
Synthesizing pharmaceuticals for cancer, viral diseases, and other medical conditions is slow work. A particularly challenging chemical transformation is to start with what s known as an unactivated alkene a common molecular building block and end up with a vicinal diamine; i.e., installation of two nitrogen units into carbon carbon double bonds. The result is a chemical unit that s present in medications for influenza and colorectal cancer.
Commonly, researchers must use rare, toxic metals and harsh reaction conditions to complete this transformation. Using a more sustainable catalyst for the reaction could solve such problems. Previous research has attempted to do so, yet with only limited success. ....

United States , Satoshi Minakata , Hayato Miwa , Emily Henderson , Osaka University , Journal Of The American Chemical Society , American Chemical Society , Colorectal Cancer , ஒன்றுபட்டது மாநிலங்களில் , ஹயாடோ மிவா , எமிலி ஹென்டர்சன் , ஒசகக பல்கலைக்கழகம் , இதழ் ஆஃப் தி அமெரிக்கன் இரசாயன சமூகம் , அமெரிக்கன் இரசாயன சமூகம் , பெருங்குடல் புற்றுநோய் ,