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EULAR releases new recommendations for non-pharmacological management of SLE and SSc

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem involvement. Systemic sclerosis (SSc) or scleroderma is another rheumatic autoimmune disease that affects blood vessels, skin, and visceral organs. ....

Megan Craig , Rheumatic Diseases , Autoimmune Disease , Blood Vessels , Lupus Erythematosus , Systemic Lupus Erythematosus ,

SSc Autoantibody Identified with Link to GI Dysfunction

If validated as a biomarker, anti-gephyrin autoantibodies could help identify patients at higher risk for GI symptoms like constipation. ....

United States , Hospital For Special Surgery , New York , Subhash Kulkarni , Zsuzsannah Mcmahan , Kimberly Lakin , Johns Hopkins University In Baltimore , Weill Cornell Medical College , Johns Hopkins Scleroderma Center , Medscape Medical News , Johns Hopkins University , Special Surgery , New York City , Texas Health Science Center , Crest Syndrome , Systemic Sclerosis , Diffuse Scleroderma , Iological Marker , Gastrointestinal Disease , Di Disease , Nerve Cell , Oint Inflammation , Mass Spectrometry , Preventive Screening , Biologic Therapy ,

Autoantibodies Could Help Predict Cancer Risk in Scleroderma

The autoantibodies anti-POLR3 and monospecific anti-Ro52 were associated with increased cancer risk, while anti-centromere and anti-U1RNP were tied to reduced risk. ....

United States , Johns Hopkins , Ji Soo Kim , Livia Casciola Rosen , University Of Pittsburgh Scleroderma Center , John Hopkins University , Johns Hopkins Scleroderma Center Research Registry , Pittsburgh Scleroderma Center , Soo Kim , Crest Syndrome , Cancer Risk , Alignant Neoplasia , Oint Inflammation , Enzyme Linked Immunosorbent Assay ,

Extracellular vesicles may drive fibrosis in scleroderma

Extracellular vesicles, responsible for cell-to-cell communication, might be a driver of fibrosis in systemic sclerosis, according to a recent paper in Arthritis and Rheumatology. ....

Kitty Trask Holt , Carol Feghali Bostwick , Megan Craig , University Of South Carolina , National Institutes Of Health , Scleroderma Research , Medical University , South Carolina , National Institutes , Distinguished Professor , Kitty Trask Holt Endowed Chair ,

Systemic Sclerosis Without Skin Fibrosis Can Still Be Severe

Nearly half of these patients had interstitial lung disease and had similar rates of scleroderma renal crisis, compared with the other disease subtypes. ....

United States , Dinesh Khanna , Alain Lescoat , Rennes University Hospital , Michigan Scleroderma Program , Ann Arbor , Medscape Medical , European Scleroderma Trials , Crest Syndrome , Systemic Sclerosis , Diffuse Scleroderma , Interstitial Lung Disease , United Kingdom Site Content , Spider Vein ,