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La Serna takes on Corona del Mar on Friday in the CIF-SS Division 4 championship game. The Lancers are hoping to win school's third championship and first since 2013.
The team is going for its sixth championship and first since 2009 in Friday's CIF-SS Division 8 championship game.
Sereno led Simi Valley on a game-winning, 73-yard drive in the final minutes to help the team secure a championship spot.
Charter Oak's Corin Berry threw three touchdown passes and ran for another in Friday's semifinal win.