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Spironolactone, a potassium-sparing diuretic typically used to treat heart failure and hypertension, has shown promise for alcohol use disorder, a common condition with few treatment options.
Substance abuse and addiction represent a significant public health problem that impacts multiple dimensions of society, including healthcare, the economy, and the workforce. In 2021, over 100,000 drug overdose deaths were reported in the US, with an alarming increase in fatalities related to opioids and psychostimulants. Understanding the fundamental gene regulatory mechanisms underlying addiction and related behaviors could facilitate more effective treatments. To explore how repeated drug exposure alters gene regulatory networks in the brain, we combined capped small (cs)RNA-seq, which accu...
The self-administered spray using a calcium-channel blocker, seen as faster-acting than a pill-in-the-pocket, usually terminated multiple bouts of the arrhythmia over months of use in a cohort study.
Background: High-density microarray patch (HD-MAP) vaccines may increase vaccine acceptance and use. We aimed to ascertain whether professional immunizers (PIs) and other healthcare workers (HCWs) in Australia, a High-Income Country (HIC), found the HD-MAP applicator usable and acceptable for vaccine delivery. Methods: This feasibility study recruited PIs and HCWs to administer/receive simulated HD-MAP administration, including via self-administration. We assessed usability against essential and desirable criteria. Participants completed a survey, rating their agreement to statements about HD-...
Dublin, Feb. 08, 2022 (GLOBE NEWSWIRE) -- The "Delivery Systems for Repositioning IV Therapeutics" report has been added to ResearchAndMarkets.com's...