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Frontiers | Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction

Substance abuse and addiction represent a significant public health problem that impacts multiple dimensions of society, including healthcare, the economy, and the workforce. In 2021, over 100,000 drug overdose deaths were reported in the US, with an alarming increase in fatalities related to opioids and psychostimulants. Understanding the fundamental gene regulatory mechanisms underlying addiction and related behaviors could facilitate more effective treatments. To explore how repeated drug exposure alters gene regulatory networks in the brain, we combined capped small (cs)RNA-seq, which accurately captures nascent-like initiating transcripts from total RNA, with Hi-C and single nuclei (sn)ATAC-seq. We profiled initiating transcripts in two addiction-related brain regions, the prefrontal cortex (PFC) and the nucleus accumbens (NAc), from rats that were never exposed to drugs or were subjected to prolonged abstinence after oxycodone or cocaine intravenous self-administration (IVSA). In ....

United States , San Diego , Lisa Maturin , University Of California , National Institutes Of Health , Genomics Center , Conversion Software Illumina , College Of Wisconsin , Diversity Program , Library Preparation , University Of Tennessee Health Science Center , Novogen Inc , Nuclei Library Preparation , Transcribed Regulatory Elements , Supplementary Table , Supplementary Figure , Transcriptional Start Regions , Region Specificity , Transcriptional Start Site Regions , Naive Rats Reveals Activated , Transcriptional Start Sites , Delos Santos , Type Specificity , Associated With Addiction Like , Supplementary Figures , Solberg Woods ,

Lexogen Introduces CORALL RNA-Seq V2 - a fast and flexible whole transcriptome RNA-Seq Library Prep Kit.

/PRNewswire/ Lexogen, a transcriptomics and Next-Generation Sequencing company today announced the release of the new CORALL RNA-Seq V2 whole transcriptome. ....

United States , New Hampshire , Amra Dedic , Pamela Nicholson , Prnewswire Lexogen , University Of Bern , Lexogen Corall Library , Next Generation Sequencing , Seq Library , Next Generation Sequencing Platform ,

Lexogen Introduces CORALL RNA-Seq V2 - a fast and flexible whole transcriptome RNA-Seq Library Prep Kit.

Lexogen Introduces CORALL RNA-Seq V2 - a fast and flexible whole transcriptome RNA-Seq Library Prep Kit.
laragione.eu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from laragione.eu Daily Mail and Mail on Sunday newspapers.

United States , New Hampshire , Pamela Nicholson , Amra Dediccommunication , Library Prep Kit , University Of Bern , Lexogen Corall Library , Next Generation Sequencing , Seq Library , Next Generation Sequencing Platform , Event Managertel ,

Lexogen Introduces CORALL RNA-Seq V2 - a fast and flexible whole transcriptome RNA-Seq Library Prep Kit.

Lexogen Introduces CORALL RNA-Seq V2 - a fast and flexible whole transcriptome RNA-Seq Library Prep Kit.
finanznachrichten.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from finanznachrichten.de Daily Mail and Mail on Sunday newspapers.

United States , New Hampshire , Amra Dedic , Kostenloser Wertpapierhandel , Pamela Nicholson , Prnewswire Lexogen , Library Prep Kit , University Of Bern , Lexogen Corall Library , Next Generation Sequencing , Seq Library , Next Generation Sequencing Platform ,

Lexogen Introduces CORALL RNA-Seq V2 - a fast and flexible whole transcriptome RNA-Seq Library Prep Kit.

/PRNewswire/ Lexogen, a transcriptomics and Next-Generation Sequencing company today announced the release of the new CORALL RNA-Seq V2 whole transcriptome. ....

United States , New Hampshire , Amra Dedic , Pamela Nicholson , Prnewswire Lexogen , University Of Bern , Lexogen Corall Library , Next Generation Sequencing , Seq Library , Next Generation Sequencing Platform ,