The Indian Pharmacopoeia Commission s advisory alerts users about Meftal s dangers, specifically its active ingredient mefenamic acid, linked to severe allergic reactions like DRESS syndrome. This syndrome, a type 4 hypersensitivity reaction, causes skin issues, fever, and organ abnormalities. Meftal s risks extend to stomach ulcers, bleeding, and kidney problems with prolonged use. Users are urged to consult doctors, avoid self-medication, and prioritize safety, emphasizing informed decision-making when considering this widely used painkiller.
FDA Advisory Committee Votes: neffy Data Support a Favorable Benefit-Risk Assessment in Adults and in Children <18 years of age and ≥30 kg If Approved, neffy Will Become the First Needle-Free. | May 11, 2023
FDA Advisory Committee Votes: neffy Data Support a Favorable Benefit-Risk Assessment in Adults (16:6 in Favor) and in Children <18 years of age and ≥30.
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Background Currently, disease control in patients with severe eosinophilic asthma is not optimistic. Competing endogenous RNA (ceRNA) networks have been found to play a key role in asthma in recent years. However, it is unclear whether ceRNA networks play an important part in severe eosinophilic asthma. Methods Firstly, gene expression profiles related to severe eosinophilic asthma were downloaded from the Gene Expression Omnibus (GEO) database. Secondly, the key modules were identified by the weighted gene co-expression network analysis (WGCNA). Thirdly, genes in modules highly associated with severe eosinophilic asthma were selected for further construction of the ceRNA network. Fourthly, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed on hub genes. Finally, the results of this study were validated on the GSE143303, GSE137268, and GSE147878 datasets. Results 22 severe eosinophilic asthmatics and 13 healthy controls were extract