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New medication offers promising treatment option for advanced melanoma patients

A new study conducted in Finland has discovered a new medication that could offer a new treatment option for patients with advanced melanoma, the most dangerous form of skin cancer. The medication, relatlimab, has been found to affect the immune system in a different way compared to other therapies that activate the immune system.

Typically, therapies have been designed to activate T cells to attack cancer cells. ....

Eteläuomen Läi , United States , Sigrid Juselius , University Of Helsinki , Aalto University , Cancer Foundation Finland , Cancer Center , Academy Of Finland , European Research Council , Precision Cancer Medicine ,

Men are biologically older than women, study finds

A study at the University of Jyväskylä found that men are biologically older than women. The observed sex difference is partially explained by men's more frequent smoking and larger body size. ....

Eteläuomen Läi , Sigrid Juselius , Elina Sillanp , Juho Vainio , Anna Kankaanp , Emily Henderson , University Of Helsinki , Gerontology Research Center , Institute For Molecular Medicine Finland , Human Sciences , University Of Jyv , Academy Of Finland , Methodology Center , Health Sciences , Doctoral Researcher , Genomics Industry Focus , Finnish Twin , Molecular Medicine Finland , Life Expectancy ,

Novel therapy-resistance mechanism promoting the growth of breast cancer brain metastasis

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IMAGE: SORLA removal sensitizes metastatic breast cancer cells to HER2 targeting therapy. Aggressive metastatic breast cancer cells growing in the brains of fish embryos. The tumors are resistant to anti-HER2 therapy.
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Credit: Ilkka Paatero from Turku Bioscience
SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells. Professor Johanna Ivaska s research group at Turku Bioscience observed that SORLA functionally contributes to the most reported therapy-resistant mechanism by which the cell-surface receptor HER3 counteracts HER2 targeting therapy in HER2-positive cancers. Removing SORLA from cancer cells sensitized anti-HER2 resistant breast cancer brain metastasis to targeted therapy. ....

Hussein Al Akhrass , Turku Bioscience , Johanna Ivaska , Academy University , University Of Turku , Sigrid Juselius Foundation , Post Doctoral Researcher Hussein Al Akhrass , Finnish Cancer Organisations , Sigrid Juselius , டர்கு உயிர் அறிவியல் , கலைக்கழகம் பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் டர்கு , பின்னிஷ் புற்றுநோய் ஆர்கநைஸேஶந்ஸ் ,