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Researchers Identify Potential Targets for Novel Treatments for Lung Cancer
Lung cancer is the most common cause of cancer deaths, accounting for about a third of all tumor-related deaths. Adenocarcinomas, a non-small cell lung cancer (NSCLC), account for about 40 percent of cancer diagnoses, but few treatments are available for the disease.
A team of investigators led by Elena Levantini, PhD, a research associate in Hematology-Oncology in the laboratory of Daniel Tenen MD, at Beth Israel Deaconess Medical Center (BIDMC), evaluated a novel agent, PTC596, capable of decreasing tumor growth in preclinical studies performed on a mouse model of mutant K-RAS lung cancer. The research – performed in collaboration with the Cancer Science Institute of Singapore at the National University of Singapore (CSI NUS) – were published today in the journal Communications Biology. The findings, which represent a comprehensive snapshot of the tumor’s components, will faci ....

United States , National University Of Singapore , Singapore General , Junyan Zhang , Henry Yang , John Clohessy , Mahmoud Bassal , Jia Li , Azhar Ali , Eva Csizmadia , Nicole Pandell , Indira Krishnan , Raphael Bueno , Giorgia Maroni , Allon Klein , Danielg Tenen , Regione Toscana Bando , Riccardo Panella , Elena Levantini , Olivier Kocher , Valerie Myami , National Cancer Institute , Beth Israel Deaconess Medical Center , University Of Alabama At Birmingham , American Society Of Hematology , Cancer Science Institute Of Singapore ,