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Small heat-shock proteins (sHsps) are a family of ubiquitous intracellular molecular chaperones that play a vital role in protein homeostasis (proteostasis). It is commonly accepted that these chaperones work by trapping misfolded proteins to prevent their aggregation. However, fundamental questions regarding the molecular mechanisms by which sHsps interact with misfolded proteins remain unanswered. The dynamic and polydisperse nature of mammalian sHsp oligomers has made these chaperones notoriously challenging to study using traditional biochemical approaches. Over the past few decades, singl...

PacBio Announces Record Preliminary Fourth Quarter 2021 Revenue, New Sequencing Kits and Workflows, and Expanded Collaborations MENLO PARK, Calif. - January 11,... | January 11, 2022

The study will evaluate the impact of high-resolution genomes generated on PacBio technology in studying unsolved rare disease cases...

Bacterial DNA replication is a potential novel antibiotic target in the fight against increasing anti-microbial resistance. To fully explore those opportunities, a full understanding of the molecular mechanisms underlying DNA replication is required. The components of the bacterial replisome, the multi-protein machinery responsible for replication, have been characterised extensively over the past 60 years, largely relying on the E. coli model system. However, the intricacies of the nucleo-protein network of the replisome and the complexity of its molecular steps have impeded our ability to pr...

Helicases involved in genomic maintenance are a class of nucleic-acid dependent ATPases that convert the energy of ATP hydrolysis into physical work to execute irreversible steps in DNA replication, repair, and recombination. Prokaryotic helicases provide simple models to understand broadly conserved molecular mechanisms involved in manipulating nucleic acids during genome maintenance. Our understanding of the catalytic properties, mechanisms of regulation, and roles of prokaryotic helicases in DNA metabolism has been assembled through a combination of genetic, biochemical, and structural meth...