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PanCAN’s Scientific & Medical Advisory Board (SMAB) welcomes new leadership and members, representing the foremost expertise in the field of pancreatic cancer from institutions across the US.
/PRNewswire/ -- The Pancreatic Cancer Action Network (PanCAN) received a $25 million gift that will accelerate the organization's critical research initiatives...
Date Time Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis Researchers at The University of Texas MD Anderson Cancer Center have discovered that mutant KRAS and p53, the most frequently mutated genes in pancreatic cancer, interact through the CREB1 protein to promote metastasis and tumor growth. Blocking CREB1 in preclinical models reversed these effects and reduced metastases, suggesting an important new therapeutic target for the deadly cancer. “To our knowledge, this is the first study to show how these two major genetic drivers work together to promote tumor growth an...