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City of Hope, TGen Researchers Develop Machine-Learning Tool to Detect Cancer Earlier via Liquid Biopsy

City of Hope, TGen Researchers Develop Machine-Learning Tool to Detect Cancer Earlier via Liquid Biopsy
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City of Hope, TGen Researchers Develop Machine-Learning Tool to Detect Cancer Earlier via Liquid Biopsy

City of Hope, TGen Researchers Develop Machine-Learning Tool to Detect Cancer Earlier via Liquid Biopsy
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Biomarker predicts bowel cancer recurrence

A biomarker in the blood of patients with bowel cancer may provide valuable insight into the risk of cancer relapse after surgery and the effectiveness of chemotherapy.

Research published in PLOS found circulating tumor DNA (ctDNA) measured before and after surgery provided a reliable marker for predicting whether the cancer would recur following chemotherapy treatment. ....

United States , Johns Hopkins , Peter Maccallum Cancer Centre , National Institutes Of Health , John Templeton Foundation , Victorian Cancer Agency Clinical Research Fellowship , Dk Ludwig Fund For Cancer Research , Associate Professor Jeanne Tie , Western Health , Professor Tie , National Institutes , Cancer Research , Victorian Government , Sol Goldman Sequencing Facility , John Templeton , Cell Biology , ஒன்றுபட்டது மாநிலங்களில் , ஜான்ஸ் ஹாப்கின்ஸ் , பீட்டர் மக்காலம் புற்றுநோய் மையம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , ஜான் கோயில் அடித்தளம் , ட்கே லுட்விக் நிதி க்கு புற்றுநோய் ஆராய்ச்சி , மேற்கு ஆரோக்கியம் , தேசிய நிறுவனங்கள் , புற்றுநோய் ஆராய்ச்சி , விக்டோரியன் அரசு ,

Mutant Gene-Targeted Immunotherapy Approach Developed

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This news release, issued by Johns Hopkins Medicine, describes a novel targeted immunotherapy approach. This new approach employs bispecific antibodies to treat cancer by eliciting a Tcell response against mutated p53. The researchers used the Highly Automated Macromolecular Crystallography (AMX) and Frontier Microfocusing Macromolecular Crystallography (FMX) beamlines to characterize the molecular structure of the proteins. AMX and FMX are beamlines at the National Synchrotron Light Source II (NSLS-II) a U.S. Department of Energy (DOE) Office of Science User Facility at Brookhaven National Laboratory. NSLS-II offers a comprehensive suite of life science research capabilities. Johns Hopkins media contacts: Amy Mone, 410-614-2915, amone@jhmi.edu, or Valerie Mehl, 410-614-2916, mehlva@jhmi.edu. Brookhaven Lab media contacts: Cara Laasch, 631-344-8458, laasch@bnl.gov or Peter Genzer, 631-344-3174, genzer@bnl.gov. ....

United States , Michaelb Murphy , Shibin Zhou , Valerie Mehl , Emily Han , Nickolas Papadopoulos , Michael Hwang , Evangeline Watson , Katharine Wright , Astra Zeneca Medimmune Amplimmune , Katharinem Wright , Yana Li , Elizabeth Cook , Patricka Brown , Gabriel Ghiaur , Bristol Myers Squibb , Bert Vogelstein , Kenneth Kinzler , Suman Paul , P Aitana Azurmendi , Sandra Gabelli , Chetan Bettegowda , Chung Hsiue , Michelles Miller , Andrew Skora , Sarahr Dinapoli ,

Mutant gene-targeted immunotherapy approach developed

Two of the three research studies led by Jacqueline Douglass, M.D., Ph.D. candidate at the Johns Hopkins University School of Medicine and Emily Han-Chung Hsiue, M.D., Ph.D., postdoctoral fellow at Johns Hopkins report on a precision medicine immunotherapy approach that specifically kills cancer cells by targeting mutant protein fragments presented as antigens on the cancer cell surface.
Although common across cancer types, p53 mutations have not been successfully targeted with drugs. Genetic alterations in tumor suppressor genes often resulted in their functional inactivation.
Traditional drugs are aimed at inhibiting proteins. Inhibiting an already inactivated tumor suppressor gene protein in cancer cells, therefore, is not a feasible approach, says Hsiue, lead author on the ....

United States , Michaelb Murphy , Shibin Zhou , Emily Han , Nickolas Papadopoulos , Michael Hwang , Evangeline Watson , Katharine Wright , Astra Zeneca Medimmune Amplimmune , Katharinem Wright , Yana Li , Patricka Brown , Gabriel Ghiaur , Bristol Myers Squibb , Bert Vogelstein , Kenneth Kinzler , Suman Paul , P Aitana Azurmendi , Sandra Gabelli , Chetan Bettegowda , Chung Hsiue , Michelles Miller , Andrew Skora , Sarahr Dinapoli , Andrewd Skora , Alexanderh Pearlman ,