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McMaster scientists discover trained immune cells are highly effective against cancer


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Credit: McMaster University
Hamilton, ON (April 14, 2021) - Modified immune cells that ruthlessly kill cancerous tumours may prove a game-changer for people living with late-stage cancer.
McMaster University researchers Ali Ashkar and Sophie Poznanski have uncovered that changing the metabolism of natural killer (NK) immune cells allows these cells to overcome the hostile conditions found inside tumours and destroy advanced ovarian and lung cancer.
In the past decade cancer immunotherapy has achieved tremendous therapeutic effects in patient with blood cancers. However, the immunosuppressive conditions found inside solid tumours, whose aggressive growth starves surrounding healthy tissues of energy, have until now remained a formidable barrier for immune cell therapies. ....

Sophie Poznanski , Ali Ashkar , Hal Hirte , Veronica Mcguire , Mcmaster University , Cancer Centre Foundation , Canada Research , Canadian Institutes For Health Research , Faculty Of Health Sciences , Hamilton Health Sciences , Master University , Mcmaster Phd , Cell Metabolism , Canada Research Chair , Natural Immunity , Hamilton Health , Canadian Institutes , Health Research , Juravinski Hospital , Cancer Centre , Health Sciences , அலி அஷ்கர் , வெரோனிகா மக்வைர் , மக்மாஸ்டர் பல்கலைக்கழகம் , புற்றுநோய் மையம் அடித்தளம் , கனடா ஆராய்ச்சி ,

Novel immunotherapy combination can be highly effective for treating lung cancer


Novel immunotherapy combination can be highly effective for treating lung cancer
McMaster University researchers have established in lab settings that a novel combination of two forms of immunotherapy can be highly effective for treating lung cancer, which causes more deaths than any other form of cancer.
The new treatment, yet to be tested on patients, uses one form of therapy to kill a significant number of lung tumor cells, while triggering changes to the tumor that enable the second therapy to finish the job.
The first therapy employs suppressed natural killer immune cells by extracting them from patients tumors or blood and supercharging them for three weeks. The researchers condition the cells by expanding and activating them using tumor-like feeder cells to improve their effectiveness before sending them back into battle against notoriously challenging lung tumors. ....

United States , Yaron Shargall , James Allison , Sophie Poznanski , Ali Ashkar , Tasuku Honjo , Emily Henderson , Mcmaster University , Canada Research , Master University , Mcmaster Phd , Thoracic Surgery , Groote School , Healthcare Hamilton , Lung Cancer , Health Care , Natural Killer Cells , ஒன்றுபட்டது மாநிலங்களில் , ஜேம்ஸ் அல்லிசன் , அலி அஷ்கர் , எமிலி ஹென்டர்சன் , மக்மாஸ்டர் பல்கலைக்கழகம் , கனடா ஆராய்ச்சி , குரு பல்கலைக்கழகம் , மக்மாஸ்டர் ஃப்ட் , தொராசி அறுவை சிகிச்சை ,

New combination of immunotherapies shows great promise for treating lung cancer


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IMAGE: McMaster researchers Ali Ashkar and Sophie Poznanski have developed a promising new form of treatment for lung cancer using a combination of two immunotherapies.
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Credit: Georgia Kirkos, McMaster University
HAMILTON, ON, Jan. 21, 2020 McMaster University researchers have established in lab settings that a novel combination of two forms of immunotherapy can be highly effective for treating lung cancer, which causes more deaths than any other form of cancer.
The new treatment, yet to be tested on patients, uses one form of therapy to kill a significant number of lung tumor cells, while triggering changes to the tumor that enable the second therapy to finish the job. ....

United States , Yaron Shargall , James Allison , Sophie Poznanski , Ali Ashkar , Tasuku Honjo , Mcmaster University , Canada Research , Master University , Mcmaster Phd , Canada Research Chair , Thoracic Surgery , Groote School , Healthcare Hamilton , Medicine Health , ஒன்றுபட்டது மாநிலங்களில் , ஜேம்ஸ் அல்லிசன் , அலி அஷ்கர் , மக்மாஸ்டர் பல்கலைக்கழகம் , கனடா ஆராய்ச்சி , குரு பல்கலைக்கழகம் , மக்மாஸ்டர் ஃப்ட் , கனடா ஆராய்ச்சி நாற்காலி , தொராசி அறுவை சிகிச்சை , க்ரூதே பள்ளி , சுகாதாரம் ஹாமில்டன் ,