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IJMS | Free Full-Text | Synthesis, Physicochemical Characterization using a Facile Validated HPLC Quantitation Analysis Method of 4-Chloro-phenylcarbamoyl-methyl Ciprofloxacin and Its Biological Investigations

A novel derivative of ciprofloxacin (Cpx) was synthesized and characterized using various analytical techniques, including FT-IR spectroscopy, UV-Vis spectroscopy, TEM and SEM analysis, 1H NMR, 13C NMR, and HPLC analysis. The newly prepared Cpx derivative (Cpx-Drv) exhibited significantly enhanced antibacterial properties compared to Cpx itself. In particular, Cpx-Drv demonstrated a 51% increase in antibacterial activity against S. aureus and a 30% improvement against B. subtilis. It displayed potent inhibitory effects on topoisomerases II (DNA gyrase and topoisomerase IV) as potential molecular targets, with IC50 values of 6.754 and 1.913 µg/mL, respectively, in contrast to Cpx, which had IC50 values of 2.125 and 0.821 µg/mL, respectively. Docking studies further supported these findings, showing that Cpx-Drv exhibited stronger binding interactions with the gyrase enzyme (PDB ID: 2XCT) compared to the parent Cpx, with binding affinities of −10.3349 and −7.7506 ....

Kafr Elsheikh , Kafr Ash Shaykh , Kafr El Sheikh , College Of Science , Al Qahirah , Saudi Arabia , Al Minya , College Of Agriculture , Al Jizah , New Valley , Al Wadi Jadid , United Arab Emirates , Ar Riya , El Awamer , Department Of Chemistry , United Arab Emirates University , Sohag University , Department Of Medical Microbiology , Chemistry Department , Taibah University , Deraya University , Department Of Pharmaceutical Analytical Chemistry , Valley University , Department Of Medical Laboratory Technology , Department Of Pharmaceutical Chemistry , Department Of Pharmaceutics ,

"List of Accredited Private Universities in Egypt: Avoiding Fake Degrees and Choosing the Right Institution

2023-08-15 07:18:00 ....

Al Qahirah , United Kingdom , Beni Suef , Bani Suwayf , College Of Veterinary Medicine , Ash Sharqiyah , Al Jizah , Al Isma Iliyah , Ad Daqahliyah , Al Iskandariyah , Saeed Al Ahlia , Mohamed Sobhy , Giza University , German University , Ismailia University , Badr University In Assiut , Sharq University , Misr University For Science , French University , Misr International University , Ministry Of Higher Education , Al Nahda University In Beni Suef , Nile University , Port Said National University , Heliopolis University , Salhia University ,

IHG Hotels signs for new Egypt property

IHG Hotels & Resorts has signed a management agreement with Mabany Edris, a well-known real estate owner and developer in Egypt, to open Holiday Inn New Assiut Asayla. ....

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IHG Expands Footprint In Egypt With Signing Of Holiday Inn New Assiut Asayla – Hospitality Net


IHG
® Hotels & Resorts, one of the world s leading hotel companies, has signed a Management Agreement with Mabany Edris, a well-known real estate owner and developer in Egypt, to open Holiday Inn New Assiut Asayla. The hotel was signed at a ceremony in Egypt in presence of Abdel Fattah Al-Assi, Assistant Minister of Tourism and Antiquities and Mohamad Anwar, Deputy Head of Urban Communities Authorities. IHG has a strong legacy in Egypt, having opened its first hotel in 1980s, and currently operates over 2000 rooms and have more than 800 rooms in the pipeline, across brands.
The announcement follows several high-profile signings this year, across IHG luxury and lifestyle, premium, essentials and suites collections, underscoring the company s progressive expansion plans across the MEA region. Further, the signing strengthens IHG s mainstream portfolio in MEA, in line with demands across key markets in the region. ....

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IHG Expands Footprint In Egypt With Signing Of Holiday Inn New Assiut Asayla – Hospitality Net

IHG Expands Footprint In Egypt With Signing Of Holiday Inn New Assiut Asayla – Hospitality Net
hospitalitynet.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from hospitalitynet.org Daily Mail and Mail on Sunday newspapers.

Al Qahirah , Nile River , Egypt General , Assiut Asayla , Mohamad Anwar , Mabany Edris , Abdel Fattah Al Assi , Holiday Inn , Sphinx University , Assiut University , Management Agreement , Holiday Inn New Assiut , Assistant Minister , Deputy Head , Urban Communities , Holiday Inn New Assiut Asayla , Holiday Inn Cairo Maadi , Holiday Inn Cairo , நைல் நதி , மஹாமட் அன்வர் , அப்தெல் படடாஹ அல் அஸ்ஸி , விடுமுறை சத்திரம் , உதவியாளர் அமைச்சர் , துணை தலை , நகர்ப்புற சமூகங்கள் , விடுமுறை சத்திரம் கெய்ரோ ,