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Validating A Better ALS Biomarker With Coya's Fred Grossman

Validating A Better ALS Biomarker With Coya's Fred Grossman
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Fred Grossman , Stanley Appel , Stanleyh Appel Department Of Neurology , Coya Therapeutics , Houston Methodist , Methodist Registry , Critical Path Innovation Meeting , Biomarker Qualification Plan , Fast Track , Relyvrio Phase ,

Coya Therapeutics to Present Proof-of-Concept Clinical Data for Low-Dose Interleukin-2 (ld IL-2) for the Treatment of Patients with Alzheimer's Disease (AD) at the 2023 Alzheimer's Association International Conference (AAIC)

The academic proof-of-concept open-label study evaluated the biological activity, cytokine and chemokine blood biomarkers, safety, and preliminary efficacy of low-dose interleukin-2 (ld IL-2) in 8 patients with mild-to-moderate AD. The study was conducted by Dr. Appel and Dr. Faridar at the Houston Methodist Hospital.



Coya’s investigational low-dose interleukin-2 (ld IL-2) for subcutaneous administration has been designed to enhance in vivo the anti-inflammatory function of regulatory T cells (Tregs).



Treg dysfunction has been associated with increased neuroinflammation, which is observed in AD and other neurodegenerative diseases, and may contribute to disease severity and progression. ....

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