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Endothelial AHR activity prevents lung barrier disruption in viral infection

Disruption of the lung endothelial–epithelial cell barrier following respiratory virus infection causes cell and fluid accumulation in the air spaces and compromises vital gas exchange function1. Endothelial dysfunction can exacerbate tissue damage2,3, yet it is unclear whether the lung endothelium promotes host resistance against viral pathogens. Here we show that the environmental sensor aryl hydrocarbon receptor (AHR) is highly active in lung endothelial cells and protects against influenza-induced lung vascular leakage. Loss of AHR in endothelia exacerbates lung damage and promotes the infiltration of red blood cells and leukocytes into alveolar air spaces. Moreover, barrier protection is compromised and host susceptibility to secondary bacterial infections is increased when endothelial AHR is missing. AHR engages tissue-protective transcriptional networks in endothelia, including the vasoactive apelin–APJ peptide system4, to prevent a dysplas ....

Apple Academic , Rr Core Team , Stem Cell , Cell Rep , Cell Biol , Cancer Res , Accurate Quantification , Genetic Analysis , Apple Academic Press , Statistical Computing ,

Age- and sex-specific hospital bed-day rates in people with and without type 2 diabetes: A territory-wide population-based cohort study of 1.5 million people in Hong Kong

In an observational cohort study, Hongjiang Wu and colleagues analyse data from more than 1.5 million people Hong Kong between 2002 and 2018 and compare age- and sex-specific rates of all-cause and cause-specific hospital bed-day rates in those with and without type 2 diabetes. ....

University Of Hong Kong , Hong Kong General , Hong Kong , United Kingdom , Daiichi Sankyo , Junshi Biosciences , Merck Serono , Astra Zeneca , Eli Lilly , R Foundation For Statistical Computing , Hospital Authority , Tricida Inc , Chinese University Of Hong Kong , Hong Kong Hospital Authority , Boehringer Ingelheim , International Classification Of Diseases , Novo Nordisk , Hong Kong Hospital , Creative Commons Attribution License , Lee Pharmaceutical , Shanghai Junshi Biosciences , Applied Therapeutics , Hua Medicine , Lee Powder , Merck Sharp , Kyowa Kirin ,

Global Burden of Cutaneous Melanoma in 2020 and Projections to 2040

This epidemiological assessment uses the GLOBOCAN database to evaluate the numbers of new cases and deaths due to cutaneous melanoma globally and by world regio ....

New Zealand , United States , United Kingdom , Lyon Cedex , Melina Arnold , Cours Albert Thomas , Australian National Health , International Statistical Classification Of Diseases , Ethics Committee , United Nations , Cancer Surveillance Branch , Human Development Index , International Agency For Research On Cancer , Research Council , R Foundation For Statistical Computing , Career Development Fellowship , Western Europe , North America , Northern Europe , International Agency , International Statistical Classification , Tenth Revision , Observational Studies , Statistical Computing , Southern Africa , Western Asia ,

Managed Critical Care: Impact of Remote Decision-Making on Patient Outcomes

This work serves as a step toward better understanding the implications of remote critical care intervention by evaluating levels of tele–intensive care unit decision-making authority. ....

United States , San Francisco , Telemed Telecare , Semin Anesth Perioper , Jamese Rogers , Matthew Aldrich , Debakey Cardiovasc , University Of Arizona , National Center , San Francisco Critical Care Innovations Group , College Of Engineering , Sepsis Campaign , Patelb Association , University Of Arizona College Medicine , Or Foundation , Telemed Je Health , Division Of Pulmonary , Department Of Medicine , University Of California , Department Of Systems , Icu Collaborative Research Database , Department Of Emergency Medicine , Chronic Health Evaluation Iva , National Heart , National Science Foundation , Acute Physiology ,

Prevalence and predictors of data and code sharing in the medical and health sciences: systematic review with meta-analysis of individual participant data

Objectives To synthesise research investigating data and code sharing in medicine and health to establish an accurate representation of the prevalence of sharing, how this frequency has changed over time, and what factors influence availability.

Design Systematic review with meta-analysis of individual participant data.

Data sources Ovid Medline, Ovid Embase, and the preprint servers medRxiv, bioRxiv, and MetaArXiv were searched from inception to 1 July 2021. Forward citation searches were also performed on 30 August 2022.

Review methods Meta-research studies that investigated data or code sharing across a sample of scientific articles presenting original medical and health research were identified. Two authors screened records, assessed the risk of bias, and extracted summary data from study reports when individual participant data could not be retrieved. Key outcomes of interest were the prevalence of statements that declared that data or code were publicly or pr ....

Ovid Embase , Kyungwan Hong , Jason Wasiak , Steve Mcdonald , Hannah Fraser , Anisa Rowhani Farid , Ovid Medline , Fiona Fidler , Veritas Health Innovation , University Of Melbourne , Australian Research Council , Rr Foundation For Statistical Computing , Department Of Health , Drug Administration , Human Services , John Arnold Foundation , Australian Commonwealth Government Research Training Programme Scholarship , Danielg Hamilton , Conclusions The , Open Science Framework , Preferred Reporting Items , Statistical Computing , Creative Commons , Sue Finch , Rebecca Hamilton , Open Access ,