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Enoch F Sam

Enoch F Sam
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Nairobi Area , Greater Accra , Volvo Research , Research Methodologies , Educational Foundation , Senior Lecturer , Transport Geographer , African Cities , Sustainable Urban Mobility , Traffic Safety , Public Transport Operations , Statistical Methods , Mixed Research ,

Single-cell quantification of ribosome occupancy in early mouse development

Translation regulation is critical for early mammalian embryonic development1. However, previous studies had been restricted to bulk measurements2, precluding precise determination of translation regulation including allele-specific analyses. Here, to address this challenge, we developed a novel microfluidic isotachophoresis (ITP) approach, named RIBOsome profiling via ITP (Ribo-ITP), and characterized translation in single oocytes and embryos during early mouse development. We identified differential translation efficiency as a key mechanism regulating genes involved in centrosome organization and N6-methyladenosine modification of RNAs. Our high-coverage measurements enabled, to our knowledge, the first analysis of allele-specific ribosome engagement in early development. These led to the discovery of stage-specific differential engagement of zygotic RNAs with ribosomes and reduced translation efficiency of transcripts exhibiting allele-biased expression. By integrating our measureme ....

Cholla Namdo , South Korea , Wiley Interdiscip , Benoit Bouvrette , Lab Chip , Ml Development , Msc Development , Ac Erice Imprinting Group , Cell Biol , Erice Imprinting , Acids Res , Statistical Methods ,