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The road to effective cancer vaccines has been long and difficult. Although initial attempts to use a vaccine to treat cancer date back to the 1910s, the first effective therapeutic vaccine would not emerge until about a century later, when Sipuleuce
At a pivotal moment in cancer vaccine research, the MIT Koch Institute Annual Symposium explored emerging successes and obstacles in the field in areas that include immunology, next-generation tools and models, and mRNA and other vaccine platforms.
Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development.
In an advance that could help scientists learn more about cancer-linked mutations whose roles are not known, MIT researchers have developed a way to easily engineer specific cancer-linked mutations into mouse models, using CRISPR prime editing.
Cancer drugs that stimulate the body’s immune system to attack tumors are a promising way to treat many types of cancer. However, some of these drugs produce too much systemic inflammation when delivered intravenously, making them harmful to use in p