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Complex Regional Pain Syndrome (CRPS): A Screening & Treatment Update motor or tropic changes The updated criteria weeds out outlier diseases, added Dr. Harden. When we tried to use the Budapest criteria as an entry into research, I have to say all heck broke loose.” There have been several trials that have failed, most likely because CRPS is a multifactorial, multi-mechanism disease. So the treatments under study are not likely to produce results with a significant P value because the population studied has different mechanisms underlying the disease. He said that the Budapest criteria should be for clinical screening purposes, and less so for research. “If you are going to be recruiting for research you need to identify what factor you are dealing with, and that should be the focus.” ....