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Researchers in the United States and Canada have described the structural basis and mode of action for two monoclonal antibodies that potently neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).
The equine navicular enthesis organ, showing structures of the navicular apparatus. Image: Osborne, Blas-Machado, Cornille, Uhl “Navicular” is a diagnosis that nobody wants to hear. The prognosis is often poor, resulting in full or partial retirement of the horse. Equine Science Foundation co-founder Paige LaBella looks at a review of the latest research, which suggests navicular syndrome might be preventable. Navicular is usually associated with front foot pain and damage to the navicular bone, deep inside the hoof structure, and any of a number of structures around it. But what if there...
Organisms with linear chromosomes have to solve the problem that DNA replication makes them shorter. This is due to the fact that DNA polymerase can only add bases to the terminal 3'-OH of a DNA chain. The DNA replication initiation complex uses RNA primers to provide the initial 3'-OH and to initiate "lagging" strand synthesis. While one strand can be copied all the way to the end of a chromosome, the other, lagging strand, must be primed at short intervals in order to provide a 3' OH group for DNA polymerase as the replication fork advances through a chromosome. The problem at the end o...
At its meeting of 9 and 10 December 2020 and upon application of Joël Mesot, President of ETH Zurich, the ETH Board appointed 14 professors. They will work in a total of ten departments in a wide range of research areas. In addition, an ecotoxicologist was awarded the title of professor. The new professors in brief: Dr Pierrick Bousseau (*1992), currently CNRS Research Fellow at the University of Paris-Saclay, France, as Assistant Professor of Mathematical Physics in the Department of Mathematics. Pierrick Bousseau conducts research in an area where algebraic geometry intersects with mathema...