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PI3K/AKT/mTOR Inhibitors for Prostate Cancer – Finally Hints of a Breakthrough

PI3K/AKT/mTOR Inhibitors for Prostate Cancer – Finally Hints of a Breakthrough
Published 05 January 2021
Activation of the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway has been strongly linked with prostate cancer progression and metastatic potential.
1 Loss of the inhibitory phosphatase, PTEN, leading to hyperactivation of PI3K/AKT/mTOR oncogenic signaling, occurs in 40-50% of metastatic castration-resistant prostate cancer.
1,2 Not surprising is the fact that PTEN loss in patients with metastatic castration-resistant prostate cancer is associated with a worse prognosis and less benefit from androgen receptor (AR) blockade.
3 Likewise, PTEN loss and subsequent Akt activation confer radiation ....

United States , Fred Hutchinson Cancer Research Center , University Of Washington , Yunfeng Li , Shunyou Wang , Evany Shi , Nicholast Ingolia , Seema Plaisier , Vivekk Arora , Ratnab Ray , Yu Chen , Ashkan Morim , Houjian Cai , Williame Friedrichs , Bretts Carver , Sarat Chandarlapaty , Merrittp Edlind , Davidp Wood , John Wongvipat , Georgej Netto , Nikolaus Schultz , Suma Raju , Evan Yu , Anuradha Gopalan , Linhm Tran , Matthewr Janes ,

50 years old who consumed hair saved from fatality at Narayana Multispeciality Hospital, HSR Layout

50 years old who consumed hair saved from fatality at Narayana Multispeciality Hospital, HSR Layout
ANI |
Updated: Dec 24, 2020 20:38 IST
Bengaluru (Karnataka) [India], December 24 (ANI/PRNewswire): Across cultures tress, especially lustrous hair is considered as a benchmark of beauty. It is beheld as an asset. What if it the same asset becomes a reason for one s fatality. That was the case with Mrs. Geeta (Name changed) whom the doctors at Narayana Multispeciality Hospital, HSR Layout had saved recently. Mrs. Geeta (Name changed) was suffering from a rare condition called trichobezoars in the intestine. The doctors had saved the patient by performing Laparatomy with Opherectomy + Enteratomy + Small Bowel Decompression. The successful procedure makes Mrs. Geeta (Name changed) the oldest patient in the world to have been operated for trichobezoars in the intestine. ....

Shivakumar Varakanahalli , James Sundeep Samuel , Suma Raju , Shashidharag Matta , Narayana Multispeciality Hospital , Small Bowel , Geeta Unlike , Small Bowel Decompression , Surgical Gastroenterology , Consultant Emergency Medicine , Harishkrishna Reddy , Medical Gastroenterology , Gundurao Harsh Joshi , சிவகுமார் வரகனஹள்ளி , ஜேம்ஸ் சுந்டீப் சாமுவேல் , சுமா ராஜு , நாராயணா பன்முகத்தன்மை மருத்துவமனை , சிறிய குடல் , கீத போலல்லாமல் , சிறிய குடல் டிகம்பரஷ்ஷன் , அறுவை சிகிச்சை இரைப்பை குடல் , ஆலோசகர் அவசரம் மருந்து , மருத்துவ இரைப்பை குடல் ,

50 years old who consumed hair saved from fatality

50 years old who consumed hair saved from fatality
bignewsnetwork.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from bignewsnetwork.com Daily Mail and Mail on Sunday newspapers.

Shivakumar Varakanahalli , James Sundeep Samuel , Suma Raju , Shashidharag Matta , Narayana Multispeciality Hospital , Opherectomy Enteratomy Small Bowel , Geeta Unlike , Opherectomy Enteratomy Small Bowel Decompression , Surgical Gastroenterology , Consultant Emergency Medicine , Harishkrishna Reddy , Medical Gastroenterology , Gundurao Harsh Joshi , சிவகுமார் வரகனஹள்ளி , ஜேம்ஸ் சுந்டீப் சாமுவேல் , சுமா ராஜு , நாராயணா பன்முகத்தன்மை மருத்துவமனை , கீத போலல்லாமல் , அறுவை சிகிச்சை இரைப்பை குடல் , ஆலோசகர் அவசரம் மருந்து , மருத்துவ இரைப்பை குடல் ,