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Ancient Brazilian genomes may hold the secrets of treponemal evolutionary history - Vimarsana News

Ancient Brazilian genomes may hold the secrets of treponemal evolutionary history

Study reconstructs four ancient treponeme genomes from 2,000-year-old Brazilian remains, revealing their close relation to the bejel-causing Treponema pallidum endemicum and challenging previous hypotheses about treponeme subspecies adaptability.

In which Joe Jackson's wisdom about cancer is apparently not validated - Vimarsana News

In which Joe Jackson's wisdom about cancer is apparently not validated

Everything Everything gives you cancer Everything Everything gives you cancer There’s no cure, there’s no answer Everything gives you cancer -

Capturing the generation and structural transformations of molecular ions - Vimarsana News

Capturing the generation and structural transformations of molecular ions

Molecular ions are ubiquitous and play pivotal roles1–3 in many reactions, particularly in the context of atmospheric and interstellar chemistry4–6. However, their structures and conformational transitions7,8, particularly in the gas phase, are less explored than those of neutral molecules owing to experimental difficulties. A case in point is the halonium ions9–11, whose highly reactive nature and ring strain make them short-lived intermediates that are readily attacked even by weak nucleophiles and thus challenging to isolate or capture before they undergo further reaction....

Source: nature.com
Catalytic asymmetric cationic shifts of aliphatic hydrocarbons - Vimarsana News

Catalytic asymmetric cationic shifts of aliphatic hydrocarbons

Asymmetric catalysis is an advanced area of chemical synthesis, but the handling of abundantly available, purely aliphatic hydrocarbons has proven to be challenging. Typically, heteroatoms or aromatic substructures are required in the substrates and reagents to facilitate an efficient interaction with the chiral catalyst. Confined acids have recently been introduced as tools for homogenous asymmetric catalysis, specifically to enable the processing of small unbiased substrates1. However, asymmetric reactions in which both substrate and product are purely aliphatic hydrocarbons have not previou...

Source: nature.com
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses - Vimarsana News

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL...

Source: nature.com