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Group A Streptococcus (GAS) M and M-like proteins are essential virulence factors and represent the primary epidemiological marker of this pathogen. Protein sequences encoding 1054 M, Mrp and Enn proteins, from 1668 GAS genomes, were analysed by SplitsTree4, partitioning around medoids and co-occurrence. The splits network and groups-based analysis of all M and M-like proteins revealed four large protein groupings, with multiple evolutionary histories as represented by multiple edges for most splits, leading to ‘M-family-groups’ (FG) of protein sequences: FG I, Mrp; FG II, M protein and Pr...

Johnson&johnson remain very good at doing that. you can't expect this kind of vaccine also to be highly effective against highly asymptomatic, that's good for the rotovirus or flu vaccine. you can get control of this infection by just having protection against moderate severe critical disease. so i think when people are holding up the bar of trying to get protection against asymptomatic or mildly symptomatic, that's too high a bar. i think we are scaring ours unnecessarily. >> is the answer at some point we will need booster shots sooner than later? similar to flu shot? i get one every fall? >...