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"Molecular characterization of the interaction between human IgG and th" by Emma Jayne Proctor, Hannah R. Frost et al.

Group A Streptococcal M-related proteins (Mrps) are dimeric α-helical-coiled-coil cell membrane-bound surface proteins. During infection, Mrp recruit the fragment crystallizable region of human immunoglobulin G via their A-repeat regions to the bacterial surface, conferring upon the bacteria enhanced phagocytosis resistance and augmented growth in human blood. However, Mrps show a high degree of sequence diversity, and it is currently not known whether this diversity affects the Mrp–IgG interaction. Herein, we report that diverse Mrps all bind human IgG subclasses with nanomolar affinity, with differences in affinity which ranged from 3.7 to 11.1 nM for mixed IgG. Using surface plasmon resonance, we confirmed Mrps display preferential IgG-subclass binding. All Mrps were found to have a significantly weaker affinity for IgG3 (p < 0.05) compared to all other IgG subclasses. Furthermore, plasma pulldown assays analyzed via Western blotting revealed that all Mrp were able to bind IgG ....

Groupa Streptococcal , Streptococcalm Related , Binding Affinity , Inding Stoichiometry , Groupa Streptococcus , Mmunoglobulin G , M Protein Family , M Related Protein , Streptococcus Pyogenes , Ubclass Preferences ,

"Streptococcus pyogenes emm98.1 variants activate inflammatory caspases" by Jonathan G. Williams, Ronald Sluyter et al.

The human pathogen Streptococcus pyogenes (Group A Streptococcus, GAS) is responsible for invasive disease characterized by inflammation and tissue destruction. Inflammatory symptoms of invasive disease may be attributed to the neutrophil response during the early stages of infection. Here, the human neutrophil response to GAS was characterized in vitro using emm98.1 type covS mutant GAS strain NS88.2 (isolated from invasive infection) and avirulent variant NS88.2rep. NS88.2 was shown to resist phagocytic killing and proliferate in the presence of human neutrophils, where neutrophil antimicrobial defence through the production of reactive oxygen species was reduced compared with NS88.2rep. In the presence of NS88.2, neutrophil death was delayed compared with NS88.2rep. Infection with either GAS strain induced expression of inflammatory caspases-1 and -4 in neutrophils, with increased detection of activated inflammatory caspases in response to NS88.2rep compared with NS88.2. NS88.2 infe ....

Groupa Streptococcus , Ell Death , Streptococcus Pyogenes ,

Argentina: Invasive Group A Streptococcus situation, Cases up in 2023

Argentina: Invasive Group A Streptococcus situation, Cases up in 2023
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Buenos Aires , Distrito Federal , Santa Fe , Northern Ireland , United Kingdom , Ministry Of Health The Nation , Pan American Health Organization , World Health Organization , Argentina National Ministry Of Health , National Health Surveillance System , Argentina National Ministry , Streptococcus Pyogenes , Tierra Del Fuego , Member States , Great Britain ,

ZONOSanitech Appoints Jim Patton as New Executive Vice President

Atlanta, GA (PRWEB) June 09, 2023 ZONOSanitech™ is pleased to announce the promotion of Jim Patton to Executive Vice President, April 1, 2023. Patton ....

Tracy Doucet , Walter Mann , Linkedina Facebook , Engineering At Techtronic Industries , Pentair Tool Group , Carolina State University , Marketing Communications Coordinator , Jim Patton , Executive Vice President , Techtronic Industries , Electrolux Appliances , Electrical Engineering , North Carolina State , Ozone Disinfecting , Sanitizing Cabinet , Respiratory Syncytial Virus , Communications Coordinator , Disinfecting Level , Sanitizing Level , Methicillin Resistant Staphylococcus , Escherichia Coli , Streptococcus Pyogenes , Salmonella Enteritidis , Pseudomonas Aeruginosa , Press Release ,

ZONO Technologies Appoints Tracy Doucet as New President

Atlanta, GA (PRWEB) March 13, 2023 ZONO Technologies is pleased to announce the appointment of Tracy Doucet as the company’s new president, effective ....

United States , Georgia State University , Walter Mann , Tracy Doucet , Bachelor Of Business Administration , University Of Central Florida , Women Interactive Network Employee Resource Group , African American Employee Network , Kimberly Clark Corporation , Marketing Communications Coordinator , Chief Executive Officer , Business Administration , Management Information Systems , Compass Award , American Employee Network , African American , Mosaic Award , Interactive Network Employee Resource , Sanitizing Cabinets , Respiratory Syncytial Virus , Communications Coordinator , Disinfecting Level , Sanitizing Level , Methicillin Resistant Staphylococcus , Escherichia Coli , Streptococcus Pyogenes ,