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"Synergy detection: A practical guide to statistical assessment of pote" by Elli Makariadou, Xuechen Wang et al.

Combination treatments have been of increasing importance in drug development across therapeutic areas to improve treatment response, minimize the development of resistance, and/or minimize adverse events. Pre-clinical in-vitro combination experiments aim to explore the potential of such drug combinations during drug discovery by comparing the observed effect of the combination with the expected treatment effect under the assumption of no interaction (i.e., null model). This tutorial will address important design aspects of such experiments to allow proper statistical evaluation. Additionally, it will highlight the Biochemically Intuitive Generalized Loewe methodology (BIGL R package available on CRAN) to statistically detect deviations from the expectation under different null models. A clear advantage of the methodology is the quantification of the effect sizes, together with confidence interval while controlling the directional false coverage rate. Finally, a case study will showcas ....

Biochemically Intuitive Generalized Loewe , Drug Combination ,

Go! & Do: Bend-area events calendar for May 2-8 | lifestyle

First Friday Art Walk, Beauty and the Beast the Musical, Cinco de Mayo Dance Party and more on deck. ....

United States , Deschutes Historical Museum , Pine Meadow , School Camp , Community Church , Harney Basin , Miller Landing , Broken Top , Region Flamande , Community Center , Downtown Bend Public Library , Waldorf School Of Bend , High Desert Museum , High Desert , East Bend Public Library , Tamil Nadu , Republic Of , Camp Sherman , Trinity Episcopal Church , Shevlin Park , Tower Theatre , Israel General , Lake Creek Lodge , Robert Delong , Kevin Kraft , Jen Zalewski ,

travel jobs: Travel, tourism sector expected to add 5.82 cr jobs in India by 2033: NLB Services

The travel and tourism sector is poised for significant growth, expected to create 5.82 crore jobs in India by 2033. Despite challenges, the sector saw a quick recovery post-pandemic. In 2020, it accounted for 39 million jobs, constituting 8% of the nation s workforce. Talent demand in tourism surged by 44% in August 2023, with 1.6 million additional jobs expected in 2023. This growth trend is projected to continue, with the sector set to add 58.2 million jobs by 2033. ....

Tamil Nadu , Uttar Pradesh , Sachin Alug , Andhra Pradesh , Travel Jobs , Nlb Services ,

ExxonMobil Rolls Out Limited-Edition Fandom Fuel Kits

Grand Prix race-themed paraphernalia will be available exclusively through the Exxon Mobil Rewards+ app. ....

Sergio Perez , Troy Simms , Exxon Mobil , Fandom Fuel Kit , Fandom Fuel Kits , Grand Prix , Max Verstappen , Oracle Red Bull Racing , Miami Grand , Ormula 1 , Grand Prix , Mobile Apps , Rewards Points ,

Unleash your inner cowabunga at Costa Rica's Surf Synergy

Ride the waves and find your Zen at this all-inclusive hidden oasis. ....

United States , New York , Costa Rica , Costa Rican , Pacific Ocean , Pura Vida , Los Angeles , Joe Santini , Marcel Oliveira , Vail Health , Surf Synergy , San Jos , Rich Naha , Head Coach Marcel Oliveira , San Jose , Casa Del Cielo , Shade Time , Longevity Week , Surf Week , Gay Surf Week , Gay Surf , Standup Paddleboarding , Playa Herradura , Brazilian Jiu Jitsu , Central America , Soleil Toujours ,