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Researchers investigated the genetic underpinnings of Gestational Diabetes Mellitus (GDM) and its relationship with Type 2 Diabetes (T2D) through a genome-wide association study ((GWAS), identifying distinct and shared genetic factors.
As a central component of the human immune system, mononuclear phagocytes defend the body by absorbing bacteria, viruses, and dead or damaged cells, thus fighting off infections and helping build immunity. Researchers from ITMO University, together w
Science for just $15 USD. Painful connections Chronic pain impairs quality of life, is challenging to treat, and accompanies various diseases. Wangzhou et al. integrated bulk and single-cell RNA sequencing of ligand and receptor gene expression in the dorsal root ganglion (DRG) and various peripheral cell types from humans and mice. Computational analysis of these data enabled the construction of a connectome of potential and cell type–specific interaction points between sensory nerves and innervated tissues. With validation in a mouse model of mechanical pain, their findings suggest that ...