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Fight-or-Flight Protein Finding May Lead to New Treatments for Skeletal Muscle Disorders


Fight-or-Flight Protein Finding May Lead to New Treatments for Skeletal Muscle Disorders
April 26, 2021
Source: Skeletal Muscle Fibers (Cells) showing Striations, Teased apart 100X. Shows: 6 skeletal muscle fibers (cells), striations and multinucleate cells. [Ed Reschke/Getty Images]
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Scientists at the University of Cincinnati and colleagues report that a regulatory protein found in skeletal muscle fiber may play an important role in the body’s fight or flight response when encountering stressful situations.
The protein, fast skeletal myosin binding protein-C (fMyBP-C), plays a foundational role in the proper regulation of contractile structure and function in the body’s fast-twitch muscles, which produce sudden bursts of power to sprint into action, jump or lift heavy objects. Fast skeletal myosin binding protein-C modulates the speed and force of fast skeletal muscle contraction. ....

Sakthivel Sadayappan , Florida State University , Sadayappan Lab , University Of Cincinnati , University Of Massachusetts Medical School , Illinois Institute Of Technology , Uc Division Of Cardiovascular Health , Uc College Of Medicine , Cardiovascular Health , Massachusetts Medical School , Illinois Institute , Taejeong Song , புளோரிடா நிலை பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் ஸிந்ஸந்யாடீ , பல்கலைக்கழகம் ஆஃப் மாசசூசெட்ஸ் மருத்துவ பள்ளி , இல்லினாய்ஸ் நிறுவனம் ஆஃப் தொழில்நுட்பம் , அக் கல்லூரி ஆஃப் மருந்து , இருதய ஆரோக்கியம் , மாசசூசெட்ஸ் மருத்துவ பள்ளி , இல்லினாய்ஸ் நிறுவனம் ,

Regulatory protein in skeletal muscle fiber may play a key role in the body's fight or flight response


Regulatory protein in skeletal muscle fiber may play a key role in the body s fight or flight response
Researchers at the University of Cincinnati say a regulatory protein found in skeletal muscle fiber may play an important role in the body s fight or flight response when encountering stressful situations.
The protein, fast skeletal myosin binding protein-C (fMyBP-C), plays a foundational role in the proper regulation of contractile structure and function in the body s fast twitch muscles these muscles produce sudden bursts of power to sprint into action, jump or lift heavy objects. Fast skeletal myosin binding protein-C modulates the speed and force of fast skeletal muscle contraction. ....

Sakthivel Sadayappan , Emily Henderson , Florida State University , Sadayappan Lab , University Of Cincinnati , University Of Massachusetts Medical School , Illinois Institute Of Technology , Uc Division Of Cardiovascular Health , Uc College Of Medicine , Cardiovascular Health , Massachusetts Medical School , Illinois Institute , Taejeong Song , எமிலி ஹென்டர்சன் , புளோரிடா நிலை பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் ஸிந்ஸந்யாடீ , பல்கலைக்கழகம் ஆஃப் மாசசூசெட்ஸ் மருத்துவ பள்ளி , இல்லினாய்ஸ் நிறுவனம் ஆஃப் தொழில்நுட்பம் , அக் கல்லூரி ஆஃப் மருந்து , இருதய ஆரோக்கியம் , மாசசூசெட்ஸ் மருத்துவ பள்ளி , இல்லினாய்ஸ் நிறுவனம் ,

Fight or flight response may hinge on protein in skeletal muscular system


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Credit: Colleen Kelley/University of Cincinnati
Researchers at the University of Cincinnati say a regulatory protein found in skeletal muscle fiber may play an important role in the body s fight or flight response when encountering stressful situations.
The protein, fast skeletal myosin binding protein-C (fMyBP-C), plays a foundational role in the proper regulation of contractile structure and function in the body s fast twitch muscles these muscles produce sudden bursts of power to sprint into action, jump or lift heavy objects. Fast skeletal myosin binding protein-C modulates the speed and force of fast skeletal muscle contraction.
This response is very critical for the higher animal and human survival. Just imagine, you are walking through a forest and suddenly you see a tiger in front of you, says Sakthivel Sadayappan, PhD, a professor in the UC Division of Cardiovascular Health and Disease. You will immediately act, either to fight or run away f ....

United States , Thomas Irving , Roger Craig , John Lorenz , Kyounghwan Lee , Judith Heiny , Maicon Landim Vieira , Weikang Ma , James Mcnamara , Lisa Martin , Jose Renato Pinto , Sakthivel Sadayappan , Sadayappan Lab , American Heart Association , Illinois Institute Of Technology , American Heart Association Fellowship , National Institute Of Arthritis , Leducq Foundation , Uc College Of Medicine , University Of Cincinnati , Division Of Cardiovascular Health , Florida State University , National Institutes Of Health , University Of Massachusetts Medical School , Red Saree Inc , Uc Division Of Cardiovascular Health ,