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Scientists discovered how a mislocated protein implicated in several neurodegenerative diseases affects another protein that’s needed for normal nerve cell functioning.

Amyotrophic lateral sclerosis and frontotemporal dementia are two neurodegenerative disorders in which many cases are linked by mislocalization of the TDP-43 protein, where instead of being located in the nucleus of the cell where genes are activated, it forms aggregates outside the nucleus in multiple neurodegenerative diseases. Rare mutations in TDP-43 are known to cause ALS, but almost all cases of ALS show mislocalization of TDP-43.

Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for

Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia.

View the Key West Citizen for Friday, February 25, 2022