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A team of scientists and physicians have discovered that the immune checkpoint protein VISTA can directly turn off tumor-fighting T-cells during immunotherapy and resist treatment. The study explains that VISTA can bind to a protein called LRIG1 in T cells, which was previously only thought to promote bone and fat development. When VISTA binds to LRIG1, the researchers found, LRIG1 sends signals that suppress T cell replication, survival and function. This interaction can happen between molecules on tumor cells and on T cells, molecules on healthy cells and T cells and even between molecules o...

A Cleveland Clinic-led team of scientists and physicians have discovered that the immune checkpoint protein VISTA can directly turn off tumor-fighting T-cells during immunotherapy and resist treatment.

Steven Kabuye had been followed for sometime before two men ambushed him on his morning commute in January. Still recovering, he fled Uganda days later with bandages still on.

Producer Timothy Chan travels from Hollywood California to Ecuador for a year. He will be in the Ecuadorian Andes, Amazon jungle and major cities. This documentary will showcase the culture, lifestyle, and uniqueness of Ecuador.

Partnering with IBM allows us to push the boundaries of AI to change the way we develop and evaluate targets for cancer therapy, says Dr Chan