Hedgehog Pathway Inhibitor Improves IPF
Hedgehog pathway signaling inhibitor ENV-101 blocks signals that can lead to lung fibrosis and scarring and may lead to remodeling of early fibrosis.
Source: medscape.com
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Ziritaxestat fails to improve lung function in patients with idiopathic pulmonary fibrosis
WASHINGTON — In patients with idiopathic pulmonary fibrosis, yearly lung function decline rates did not improve with two different dosages of ziritaxestat, according to an American Thoracic Society International Conference presentation.“Unfortunately, ziritaxestat did not improve clinical outcomes compared with placebo in patients with IPF receiving standard of care,” Toby M.
Source: healio.com
Ziritaxestat, a Novel Autotaxin Inhibitor, and Lung Function in Idiopathic Pulmonary Fibrosis
These 2 randomized clinical trials compare the efficacy and safety of 2 doses of the autotaxin inhibitor ziritaxestat vs placebo in patients with idiopathic pul
Source: jamanetwork.com