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Raman imaging offers a greater potential for detecting multiple enzyme activities than fluorescence imaging, demonstrate Tokyo Tech researchers by developing 9CN-rhodol-based activatable Raman probes using a novel mechanism for Raman signal activation. The strategy allows a synthesis of highly activatable Raman probes with high aggregation and multiplexing ability, making it a promising tool for extending the range of Raman probes for the detection of multiple enzyme activities in heterogeneous biological tissues.

Today, more than half of the total energy produced by fossil fuels is lost as waste heat, accelerating global warming.

Solid oxide fuel cells (SOFCs) are a promising solution to the contemporary problem of the impending global energy crisis. SOFCs show high efficiency, lower emissions, and have low operating costs, making them an ideal power source for a fossil fuel-free society.

Tokyo Institute of Technology has selected two teams for the 2022 Interdisciplinary Research Support for Scientists Program, which supports research that transcends individual fields.This support program aims to promote interdisciplinary research tha

CycPeptMPDB, a novel database—created by Tokyo Tech researchers—focused on the membrane permeability of cyclic peptides, could accelerate the development of drugs based on these promising compounds. This database was created by gathering published information on thousands of cyclic peptides and organizing it neatly in an online-accessible platform. Thanks to its search and visualization capabilities, CycPeptMPDB could pave the way to new computational and machine learning methods for screening and designing drugs with cyclic peptides.