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Crews said they were called to the area of Stratford Road and Hillcrest Center Drive around 8:19 on Wednesday.
Crews said there were no injuries to any firefighters and do not believe anyone was in the home when the fire broke out.
When responding officers arrived, they said they found one person with a serious injury.
A feral cat had been captured southeast of Stoneville, and later tested positive for rabies, health officials said.
Police say Cameron Crawley, 9, and Caitlin Crawley, 15, were last seen Wednesday at their home at 3 a.m.