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Researchers take steps to standardize correlates of protection against SARS-CoV-2 Researchers in the UK and Germany have identified a range of assays and biomarkers of humoral (antibody) immunity against coronavirus disease 2019 (COVID-19) that can be used to define correlates of protection in future studies. Wherever suitable, antibody-based parameters were expressed in International Units (IU) and Binding Antibody Units (BAU). "The adoption of common results reporting unitage in IU and BAU as those described in this study would eventually facilitate comparative analyses of data generated by...

Study attempts to standardize humoral immune Correlates of Protection (CoP) in COVID-19 The World Health Organization (WHO) declared the coronavirus disease 2019 (COVID-19) pandemic in March 2020, owing to the rapid worldwide spread of its causative virus: severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This is a positive-sense RNA virus that causes mild to critical infection. Several COVID-19 vaccines have received emergency authorization by national regulatory authorities in different parts of the world and, subsequently, vaccination programs have been initiated in many countr...