3 Questions: Daniel Lew on what we can learn about cells from yeast
MIT Department of Biology faculty Daniel "Danny" Lew uses budding yeast to address fundamental questions in cell biology.
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MIT Department of Biology faculty Daniel "Danny" Lew uses budding yeast to address fundamental questions in cell biology.
Endocytosis is an important cellular process through which cells internalize substances such as water and nutrients.
Protein aggregates accumulate during aging and are linked to neurodegenerative diseases like Alzheimer's, Parkinson's or Huntington's disease.
Textbooks will tell you that in dividing cells, the production of new DNA peaks during the S-phase, while production of other macromolecules, such as proteins, lipids, and polysaccharides, continues at more or less the same level.
DNA replication in eukaryotic organisms is a highly intricate process involving a large number of functionally and structurally distinct proteins. Despite being significantly different from DNA replication in bacterial and viral systems, eukaryotic DNA replication mechanisms have been found to be highly conserved across all eukaryotes, from yeast to humans. The budding yeast, Saccharomyces cerevisiae, has emerged as an important model organism to understand DNA replication in eukaryotes. This thesis describes the development and application of single-molecule approaches to study DNA replicatio...