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We thank Dorien M Kimenai and Nicholas L Mills for their interest in our Article.1 Indeed, sex-specific diagnostic thresholds of troponin were introduced into the Universal Definition of Myocardial Infarction in 2012 during the recruitment period of our study and have led to increased diagnostic sensitivity in the decade since.2
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Treating T2MI requires reversing the trigger causing myocardial oxygen supply-demand mismatch plus individualized care.