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Reactive compounds cause cellular damage that is suspected to contribute to aging and neurodegenerative diseases. Oxidative stress and environmental factors likely contribute to this. Here we report that an enzyme mutated in Parkinson’s disease can prevent damage of metabolites and proteins caused by a metabolite from the central pathway of sugar metabolism. Inactivation of this enzyme in model systems, ranging from flies to human cells, leads to the accumulation of a wide range of damaged metabolites and proteins. Thus, this enzyme represents a highly conserved strategy to prevent damage in cells that metabolize sugars. Overall, we discovered a fundamental link between carbohydrate metabolism and a type of cellular damage that might contribute to the development of Parkinson’s disease.

Mass spectrometry proteomics data have been deposited at ProteomeXchange, [www.proteomexchange.org/][1] (accession no. PXD029410) via the PRIDE partner repository ([62][2]). Processed mass sp ....

United Kingdom , Fondation Contre Le , Deutsche Forschungsgemeinschaft , European Union Horizon , Didier Trono University Of Geneva , Eric Fearon University Of Michigan , University Animal Welfare Committee , European Research Council , Jp Bolanos University Of Salamanca , Feng Zhang Massachusetts Institute Of Technology , Universal Problem , Long Standing Enigma , Proteins Provides , Pleiotropic Effects , Phosphatases That Convertn Phosphoglyceroyl , N Glyceroyl Adducts Remain , Animal Welfare , Recombinant Proteins , Orbitrap Fusion Lumos , Proteome Discoverer , Cell Signaling , Cell Biolabs , Feng Zhang , Massachusetts Institute , Eric Fearon , Ann Arbor ,