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Molecular Imaging Determines Effectiveness of Novel Metastatic Breast Cancer Treatment
Reston, VA-Molecular imaging can successfully predict response to a novel treatment for ER-positive, HER2-negative metastatic breast cancer patients who are resistant to hormonal therapy. According to research published in the February issue of The Journal of Nuclear Medicine, positron emission tomography (PET) imaging using an imaging agent called
18F-fluoroestradiol can help to determine which patients could benefit from treatments that could spare them from unnecessary chemotherapy.
Nearly two-thirds of invasive breast cancers are ER-positive, and endocrine therapy is the mainstay of treatment for these tumors because of its favorable toxicity profile and efficacy. Should cancer progress in these patients, however, salvage endocrine therapy with molecularly targeted agents or chemotherapy can help. ....

United States , Czech Republic , University Of Pennsylvania , Fred Hutchinson Cancer Research Center , Kennetha Krohn , Hannahm Linden , Alena Novakova Jiresova , Fengting Yan , Vijayakrishnak Gadi , Brendaf Kurland , Davida Mankoff , Erink Schubert , Jenniferm Specht , Julier Gralow , Journal Of Nuclear Medicine , Department Of Radiology , Public Health Sciences Division , National Cancer Institute , Oregon Health , University Of Washington Seattle Cancer Care Alliance , University Of Pittsburgh , Clinical Research , Division Of Medical Oncology , Department Of Biostatistics , Cancer Imaging Program , Department Of Diagnostic Radiology ,