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1962
The Houston Colt .45s play their first Major League game on April 10, defeating the Chicago Cubs 11-2.
1963
1964
Ken Johnson becomes the first major leaguer to lose a nine-inning no-hitter on April 23 with a 1-0 loss to the Cincinnati Reds.
1965
The Houston Colt .45s become the Houston Astros and inaugurate indoor baseball with a 2-1 exhibition win over the New York Yankees on April 9 in the Astrodome.rookie Joe Morgan sets club marks for at-bats, runs, hits and triples.
1966
Mike Cuellar sets a club mark with a 2.22 ERA.home attendance mark which stood for 22 years set on June 22 as 50,908 watch Sandy Koufax and the Dodgers down Houston 5-2. ....

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