Specialized technique captures unique protein structures in neuropathy disorders
E-Mail Charcot Marie Tooth and Dejerine-Sottas syndrome are groups of diseases that involve the breakdown of the myelin sheath covering nerve axons. As this myelin sheath breaks down, people who have these disorders suffer nerve damage in the arms and legs--those with Dejerine-Sottas disease may never walk or may lose the ability to walk by the time they are teenagers. Researchers have known that a protein called PMP22, which is important for nerve myelin, is likely involved in the disease. But because the protein is so small and part of the cell membrane, it's difficult to study. Now, an i...