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PRIME, PRIME 2 Data Show 12-, 24-Week Improvements in Patients With Prurigo Nodularis

The LIBERTY-PN PRIME and PRIME2 trials investigated itch response to dupilumab among patients who have prurigo nodularis.
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Worst Itch Numeric Rating Scale , Investigator Global Assessment , Dermatology Life Quality Index , Prurigo Nodularis , Wi Nrs , Iga Pn S ,

Dupilumab Benefits Shown in Phase 3 Prurigo Nodularis Trials

The results "support the involvement of type 2 cytokines in driving PN disease pathogenesis and the targeting of the IL-4/IL-13 axis as a novel therapeutic paradigm" for PN, the authors write. ....

United States , Adam Friedman , Gil Yosipovitch , University Of Miami , Regeneron Pharmaceuticals , George Washington University , Nature Medicine , Worst Itch Numeric Rating Scale , Biologic Therapy , Prurigo Nodularis , Skin Lesion , Topical Therapy ,

Phase 2 Randomized Trial Supports Roflumilast as a Potential Treatment for Seborrheic Dermatitis

1. Erythema, scaling, and itching caused by seborrheic dermatitis (SD) significantly decreased with roflumilast treatment. 2. Roflumilast treated for SD resulted in favourable local tolerability and safety profile. Evidence Rating Level: 1 (Excellent) Study Rundown: Seborrheic dermatitis (SD) is a chronic dermatosis characterized by erythematous, scaly, and pruritic patches and plaques in areas of high ....

Rating Level , Investigator Global Assessment , Worst Itch Numeric Rating Scale , Seborrheic Dermatitis ,

Roflumilast Foam Efficacious, Safe in Treating Seborrheic Dermatitis Symptoms

New data indicate that once-daily roflumilast foam in treating seborrheic dermatitis may improve the lives of those in the 5% or more of the global population with the skin disease.
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United States , Pubmedgoogle Scholarcrossref , Matthewj Zirwas , Central States , Investigator Global Assessment , Worst Itch Numeric Rating Scale , Roflumilast Foam , Patients With Seborrheic Dermatitis , Vehicle Controlled Phase , Randomized Clinical , Cutan Med ,

A Hidden Crisis: The Need for Treatments in Notalgia Paresthetica

A silent disease characterized as a chronic cutaneous neuropathy, notalgia paresthetica has an unmet need yet to be fully understood and, dermatologists argue, an FDA-approved treatment could help improve understanding of the etiology and prevalence of this disease. ....

United States , Chris Bunick , Pamela Weinfeld , Raj Chovatiya , Brian Kim , Caridad Gomez , Mount Sinai Health System , Yale School Of Medicine , Icahn School Of Medicine At Mount Sinai , Drug Administration , Ericj Waldman Department Of Dermatology , Northwestern University , Skin Care Associates , Research For The Kimberly , Yale School , New England Journal , Icahn School , Worst Itch Numeric Rating Scale , Paresthetica Review , Notalgia Paresthetica With Botulinum Toxin Type , England Journal , Sinai Health , Published February , Published August ,