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Cryo-EM imaging of STING protein reveals new binding pocket

Imaging at near-atomic resolution of a key immune protein commonly known as STING has revealed a previously unrecognized binding site that appears to be pivotal ....

United States , Yong Lu , Zhijian James Chen , Xiaochen Bai , Georgel Macgregor , Xuewu Zhang , Guijun Shang , Jie Li , National Institutes Of Health , Haroldc Simmons Comprehensive Cancer Center , Howard Hughes Medical Institute Investigator , Research Institute Of Texas , Virginia Murchison Linthicum Scholars In Medical Research , Welch Foundation , Associate Professor , Cell Biology , Comprehensive Cancer , Molecular Biology , Host Defense , Cryo Electron Microscopy , Virginia Murchison Linthicum Scholars , Gregor Distinguished Chair , Biomedical Science , Howard Hughes Medical Institute , National Institutes , Cancer Prevention ,

Cryo-EM imaging of a key immune protein reveals a previously unrecognized binding site

Imaging at near-atomic resolution of a key immune protein commonly known as STING has revealed a previously unrecognized binding site that appears to be pivotal for launching immune attacks, UT Southwestern scientists report in a new study. ....

Zhijian James Chen , Jie Li , Emily Henderson , Yong Lu , Georgel Macgregor , Xiaochen Bai , Xuewu Zhang , Guijun Shang , Haroldc Simmons Comprehensive Cancer Center , Howard Hughes Medical Institute Investigator , Virginia Murchison Linthicum Scholars In Medical Research , Study Author , Associate Professor , Cell Biology , Comprehensive Cancer , Molecular Biology , Host Defense , Virginia Murchison Linthicum Scholars , Gregor Distinguished Chair , Biomedical Science , Howard Hughes Medical Institute , Cell Biology , Electron Microscopy ,