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Prototype Shows Promise As Approach to Countering Pancreatic Cancer
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NEW YORK, May 11, 2021 /PRNewswire/ A research team has designed a molecule with potential to interfere in a new way with altered proteins that cause abnormal growth in 35 percent of pancreatic cancers.
Published online in
Nature Communications on May 11, a new study found that a molecule called a monobody clings to cancer-causing versions of the KRAS protein and keeps them from transmitting their signals. Changes in the DNA of the
KRAS gene – which encodes a molecular switch that toggles between active and inactive states to regulate growth – cause the related protein to become stuck in the on mode. Cells with such mutations continually multiply and give rise to cancer. ....

United States , Carmine Fedele , Steven Tsai , Yingkai Zhang , Gregory Williams , Kai Wen Teng , John Obryan , Akiko Koide , Shohei Koide , Benjamin Neel , Xuben Hou , Takamitsu Hattori , National Institutes Of Health , Langone Health Perlmutter Cancer Center , Department Of Biochemistry , Department Of Cell , Langone Perlmutter Cancer Center , Nature Communications On , York University Application No , Grossman School Of Medicine , Puretech Health , Department Of Chemistry At New York University , Navire Pharmaceuticals , American Cancer Society , Perlmutter Cancer Center , Nature Communications ,