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Concept of Nanoconfinement Improves Sensitivity and Safety of a Life-saving Diagnostic Contrast Agent


April 06, 2021
Computed Tomography Scan
More than seven years ago Albert J. Sinusas, MD, a professor of medicine, radiology, and biomedical engineering, was working with a team of engineers for development of an imageable polymer for prevention of adverse remodeling after a heart attack when they inadvertently discovered that when iodine, a contrast agent used for X-ray imaging, is packed in a nanoparticle there is greater absorption of X-rays potentially improving visibility.
In development of this new concept Sinusas, who directs the Yale Translational Research Imaging Center (Y-TRIC), turned to Tarek Fahmy, PhD, an associate professor of biomedical engineering and Dongin (Donoven) Kim, PhD, now an assistant professor at the University of Oklahoma, and one of the first Y-TRIC trainees supported by an NIH T32 grant for training in multi-modality molecular and translational cardiovascular imaging, which was just renewed for an additional five years of funding. ....

Albertj Sinusas , John Stendahl , Farhad Daghighian , Tarek Fahmy , Dongin Donoven Kim , University Of Oklahoma , Yale Translational Research Imaging Center , Archives Of Pharmacal Research , Computed Tomography , தரெக் பஹ்மி , பல்கலைக்கழகம் ஆஃப் ஓக்லஹோமா , யேல் மொழிபெயர்ப்பு ஆராய்ச்சி இமேஜிங் மையம் , காப்பகங்கள் ஆஃப் மருந்தகம் ஆராய்ச்சி ,