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The brains of mice carrying different mutations in the autism-linked gene TBR1 display different molecular changes yet similar structural changes, resembling those previously found in autistic people with TBR1 mutations. ....
Preclinical study finds sex differences in neurological response to SARS-CoV-2 infection Neurological problems during and after coronavirus disease 2019 (COVID-19) are persistent and frequent. However, research is still ongoing as to why certain people exhibit specific symptoms. Research led by Yi-Ping Hsueh from the Institute of Molecular Biology in Taiwan suggests SARS-CoV-2 infection in the brain could be sex-dependent. In a preclinical model, the researchers found female mice were less susceptible to SARS-CoV-2-induced weight loss and more likely to survive than males at low doses. The study authors write: Our transgenic mice provide an appropriate model for investigating the impact of SARS-CoV-2 infection on various organs and tissues, as well as the neuropsychiatric symptoms observed in COVID-19 patients.” ....