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Polycystic Kidney Disease Treatment: Gene Target Identified at Yale

An unsuspected gene, Glis2, has been found to be a target of polycystic kidney disease (PKD) signaling in preclinical models. ....

Yiqiang Cai , Hongyu Zhao , Zemeng Wei , Jianlei Gu , Michael Rehman , Stefan Somlo , Monkol Lek , Cho Steven Pei , Chao Zhang , Felix Behrens , Antonm Jetten , Thomasa Bell , Yale School Of Medicine , Nature Communications , Yale School , Xin Tian , Lim Cho , Ming Shen Tham ,

Researchers Demonstrate XBP1 Reduces Severity of Polycystic Kidney Disease

Most families with autosomal dominant polycystic kidney disease (ADPKD) possess a genetic mutation in PKD1, that impacts the protein polycystin-1 (PC1). In a ....

United States , Carlotta Pioppini , Anna Rachel Gallagher , Parisa Westergerling , Sorin Fedeles , Thuy Anh Nguyen , David Ruemmele , Stefan Somlo , Elif Duygu Yilmaz , Tobias Staudner , Charite Universit , Yiqiang Cai , Matteus Krappitz , Journal Of The American Society Nephrology , Yale School Of Medicine , American Society , Yale School , Till Hollmann ,